Antioxidant potential and in vitro cytotoxicity study of Saraca indica extract on lead-induced toxicity in HepG2 and HEK293 cell lines

Saraca indica is an important medicinal plant and the compounds present in this are very much helpful preventing various diseases. Therefore, aim of study was to investigate antioxidant activity vitro investigation S. extract on lead-induced toxicity HepG2 HEK293 cell lines. The assay performed by two methods such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging assay. MTT used for cytotoxic human hepatocellular liver (HepG2) embryonic kidney (HEK293) IC50 values DPPH aqueous ethanolic extracts were 380 350 µg/mL, respectively. ABTS+ 200 Cell viability lines found be 50% at 800 µg/mL concentration 1000 extract. Data obtained from indicated that significantly increased a dose-dependent manner. Both involved protection against toxicity. may salvage therapy Further studies required isolate bioactive plants advanced investigation.